Paolo Barassi Selected Research

Istaroxime

1/2022	SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy.
8/2013	Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition.
9/2008	Modulation of sarcoplasmic reticulum function by PST2744 [istaroxime; (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride)] in a pressure-overload heart failure model.
1/2007	Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure.

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Paolo Barassi Research Topics

Disease

4	Heart Failure 01/2022 - 01/2007
2	Hypertrophy 09/2008 - 08/2004
2	Hypertension (High Blood Pressure) 08/2004 - 12/2002
1	Diabetic Cardiomyopathies 01/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Cardiomegaly (Heart Hypertrophy) 08/2004
1	Hyperglycemia 12/2002

Drug/Important Bio-Agent (IBA)

4	IstaroximeIBA 01/2022 - 01/2007
2	CalciumIBA 08/2013 - 01/2007
1	Pharmaceutical PreparationsIBA 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2022
1	phospholambanIBA 08/2013
1	Calcium-Transporting ATPases (Ca2+ ATPase)IBA 01/2007
1	Protein Isoforms (Isoforms)IBA 01/2007
1	Ouabain (G Strophanthin)IBA 08/2004
1	rostafuroxinIBA 12/2002
1	AldosteroneIBA 12/2002
1	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 12/2002
1	ReninIBA 12/2002
1	Antihypertensive Agents (Antihypertensives)IBA 12/2002
1	DiureticsIBA 12/2002
1	adducinIBA 12/2002

Therapy/Procedure

2	Therapeutics 08/2013 - 01/2007